What is Gabapentin ?
Gabapentin (Neurontin) is a pharmaceutical drug, specifically a GABA analog. It was originally developed to treat epilepsy, and currently is also used to relieve neuropathic pain.
NEURONTIN is a prescription medicine used to treat: Pain from damaged nerves (postherpetic pain) that follows healing ofshingles (a painful rash that comes after a herpes zoster infection) in adults. Partial seizures when taken together with other medicines in adults and children 3 years of age and older with seizures.
Gabapentin is an anti-epileptic medication, also called an anticonvulsant. It affects chemicals and nerves in the body that are involved in the cause of seizures and some types of pain. Gabapentin is used in adults to treat nerve pain caused by herpes virus or shingles (herpes zoster).
The Horizant brand Gabapentin is also used to treat restless legs syndrome (RLS). The Neurontin brand is also used to treat seizures in adults and children who are at least 6 years old.
What you should know before your buy online Gabapentin ?
Before you order Neurontin (Gabapentin ) Online, you must know the side effects of Gabapentin, and you are not listed in Who can not buy gabapentin Online. It is recommended that you only refill gabapentin online and you have your local doctor health checked and you are allowed to take gabapentin and please let your doctor know you are taking gabapentin.
You should not use gabapentin if you are allergic to it.
To make sure this medicine is safe for you, tell your doctor if you have ever had:
lung disease, such as chronic obstructive pulmonary disease (COPD);
kidney disease (or if you are on dialysis);
depression, a mood disorder, or suicidal thoughts or actions;
a seizure (unless you take gabapentin to treat seizures);
heart disease; or
are taking an anti-depressant or sedating medication; or
(for patients with RLS) if you are a day sleeper or work a night shift.
Some people have thoughts about suicide while taking this medicine. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.
It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
Seizure control is very important during pregnancy, and having a seizure could harm both mother and baby. Do not start or stop taking gabapentin for seizures without your doctor’s advice, and tell your doctor right away if you become pregnant.
Neurontin is FDA-approved for partial seizure (adjunct) in children age 3 to 12 and in adults. It is also FDA-approved for postherpetic neuralgia in adults.
How should I take gabapentin?
What is the off-label usages of gabapentin ?
Neurontin is used primarily to treat epilepsy. More specifically it treats elementary partial seizures (brief, without loss of consciousness) and complex partial seizures (consciousness impaired), with and without secondary generalization (grand mal epilepsy with loss of consciousness).
Usually it must be taken for two to three weeks to determine if it decreases the frequency or severity of seizures. Neurontin can only treat epilepsy; it is not a cure. Neurontin is also used to treat: Anxiety, Insomnia, and Chronic pain (not FDA approved for this use)
Neurontin has been used as a mood stabilizer, but some studies show that it is no more effective than a placebo in treating bipolar disorder.
By Buyinggabapentin.com, Gabapentin can be used for preventing migraine, treat nerve pain, restless legs syndrome, and Fibromyalgia. Actually Gabapentin relieves the pain of PHN by changing the way the body senses pain. You can buy Gabapentin to treat attention deficit hyperactivity disorder (ADHD), alcohol withdrawal, chronic neuropathic pain, cocaine addiction, diabetic peripheral neuropathy,generalized anxiety disorder (GAD), fibromyalgia, menopause, migraine prevention, panic disorder, post-traumatic stress disorder (PTSD), social phobia, trigeminal neuralgia.
Gabapentin can also be used for more than 30 off-label health conditions such as: Benign Essential Tremor,,Bipolar Disorder,,Burning Mouth , yndrome, Cluster-Tic Syndrome, Cough, Diabetic Peripheral Neuropathy, Epilepsy, Erythromelalgia, Fibromyalgia, Hiccups, Hot Flashes, Hyperhidrosis, Insomnia, Lhermitte’s Sign, Migraine, Nausea/Vomiting, Chemotherapy Induced, Neuropathic Pain, Occipital Neuralgia, Pain, Periodic Limb Movement Disorder, Peripheral Neuropathy, Postherpetic Neuralgia, Postmenopausal Symptoms,Pruritus,,Pudendal Neuralgia,,Reflex Sympathetic Dystrophy Syndrome, Restless Legs Syndrome, Small Fiber Neuropathy, Spondylolisthesis, Syringomyelia, Transverse Myelitis, Trigeminal Neuralgia, Vulvodynia. For more information, please check drug.com Gabapentin page.
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But you must complete the health questionnaires very honestly and carefully. The doctors must know your health condition to prescribe you the prescriptions. They may call you to discuss your health condition and medical condition and they will not prescribe you the medicines if they cannot catch you.
Gabapentin Warnings and Precautions
Neurontin has been tested in children and adolescents from 3 to 18 years old, and its effects have been found to be the same as those in adults, when dosage is appropriately adjusted. Neurontin may impair the ability to drive or operate heavy machinery.
Neurontin should not be discontinued suddenly – sudden withdrawal may cause seizures to return or occur more frequently. Dosage should be gradually tapered over at least 7 days when Neurontin is discontinued. For Pregnant or Nursing Mothers: Neurontin has not been studied in pregnant women, but other antiepileptic drugs have been known to cause birth defects. Studies in animals indicate that very high doses of Neurontin can cause bone and kidney problems. It is not known whether Neurontin passes into breast milk, and nursing mothers should be cautious about using Neurontin.
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By some websites and health professional reasearch, Gabapentin is even a better Analgesic than Tramadol. That reasearch is from a health professional group from the University of Victoria. Because tramadol is a controlled medicine now, we do suggest you order gabapentin online. We provide the cheapest authentic COD gabapentin and cod fioricet online with USPS priority mail services.
How Gabapentin is typically packaged?
Capsule: 100, 300, 400mg
Tablet: 100, 300, 400, 600, 800mg
Oral solution (brand-name only): 250mg/5mL
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Normal Dosage Of Gabapentin
USAGE FOR EPILEPSY: The usual starting dose is 300mg for adults and children over 12 years of age. This dose is taken on the evening of the first day. Your doctor may then increase the dose on the second day to 300mg in the morning, and 300mg in the evening. On the third day you may be increased to 300mg three times per day. The maximum dosage is 3600mg per day. Gabapentin is not recommended for children under 12 years.
USAGE FOR DIABETIC NERVE PAIN: The dosage follows the rules for epilepsy, and may be continued for up to 5 months. If you suffer from any kidney problems, the doctor may issue a lower dosage.
USAGE AS A NERVE BLOCK: Gabapentin is not marketed for use as a nerve block, but is commonly used as such following successful applications. The dosage follows the same rules as for epilepsy patients, with a maximum dosage of 3600mg. For chronic pain conditions, Gabapentin may need
Gabapentin Mechanism of action
The mechanism of the anticonvulsant action of gabapentin has not been fully described. Several possible mechanisms for pain improvement have been discussed. Though similar in structure to the endogenous neurotransmitter GABA, gabapentin has not been shown to bind to GABA receptors at concentrations at or below 1 mM. Gabapentin modulates the action of glutamate decarboxylase (GAD) and branched chain aminotransferase (BCAT), two enzymes involved in GABA biosynthesis. In human and rat studies, gabapentin was found to increase GABA biosynthesis, and to increase non-synaptic GABA neurotransmission in vitro.
Gabapentin prevents seizures in a wide variety of models in animals, including generalized tonic-clonic and partial seizures. Gabapentin has no activity at GABAA or GABAB receptors of GABA uptake carriers of brain. Gabapentin interacts with a high-affinity binding site in brain membranes, which has recently been identified as an auxiliary subunit of voltage-sensitive Ca2+ channels.
Gabapentin has been shown to bind to the α2δ-1 subunit of voltage gated calcium ion channels, which contributes to its pain attenuation effects in diabetic neuropathy and post-herpetic neuralgia. Other neurophysiological findings indicate that gabapentin also interacts with NMDA receptors, protein kinase C, and inflammatory cytokines.
Gabapentin prevents pain responses in several animal models of hyperalgesia and prevents neuronal death in vitro and in vivo with models of the neurodegenerative disease amyotrophic lateral sclerosis (ALS). Gabapentin is also active in models that detect anxiolytic activity.
Although gabapentin may have several different pharmacological actions, it appears that modulation of GABA synthesis and glutamate synthesis may be important.
Gabapentin Adverse Reactions
Side effects reported in children age 3 to 12 include: Aggressive behaviors / behavior problems,Anxiety, fidgeting or restlessness, Difficulty concentrating or change in school performance, Crying, False sense of well-being, Hyperactivity, Depression, Emotionally overreacting, mood swings.
Side effects in adults: Drowsiness,Dizziness, Fatigue, Clumsiness, Tremor, Nystagmus (rapid involuntary movements of the eyes), Ataxia (shaky movements and unsteady gait), Rhinitis (excessively runny nose and eyes), Nausea, Weight gain, Skin rash, Changes in vision, Vomiting, Low blood pressure, Constipation, Impotence, Lowered white blood cell count, Sleepiness, Mood swings, Hostile behavior, Disordered thinking, Hyperactive behavior
Rarely Gabapentin Side Effects: Severe skin rash (Stevens-Johnson syndrome, rare), Seizure
Gabapentin Interactions with Drugs and Other Substances
Drugs or substances that may interact with Neurontin include:
- Antacids (within 2 hours) – taking Neurontin with antacids may reduce Neurontin’s effects.
- Alcohol – frequent use of alcohol may seriously reduce the effectiveness of Neurontin.
- Tagamet (cimetidine) – may increase blood levels of Neurontin.
- Dilantin (phenytoin) – taking Neurontin with Dilantin may lead to phenytoin toxicity.
- Central nervous system (CNS) depressants, including cold medicines – these medications may add to the sedative effects of Neurontin.
Gabapentin For Migraine Prevention
International and domestic studies that have evaluated Neurontin for migraine prevention suggest that it is effective. In a study of 63 patients with migraine (with or without aura), gabapentin significantly reduced migraine frequency and intensity among 30 patients who received it. In this study, adverse events were mild to moderate in severity.
Similarly, in a large study, 143 people with migraine received daily doses of Neurontin or placebo for 12 weeks. At the end of 12 weeks, the migraine rate had declined from 4.2 migraines before treatment to 2.7 migraines after treatment in those who received this drug. This decrease was significantly greater than the decrease from 4.1 migraines to 3.5 migraines among those who received placebo. Of the 56 gabapentin recipients, 46% had at least a 50% reduction in the four-week migraine rate. Drug-related adverse events (sleepiness and dizziness) led to drug withdrawal in 13% of patients in the gabapentin group compared with 7% in the placebo group. The researchers concluded that this medication is an effective and well-tolerated preventive for migraine.
However, the American Academy of Neurology (AAN), the organization that provides guidance for the use of drugs to prevent migraines, has stated that there is not enough evidence at this time to support the use of gabapentin for migraine prevention. Healthcare professionals can choose to prescribe gabapentin when other prevention therapies have not worked, however.
Some people can prevent migraines by avoiding triggers. Others have prevented migraines successfully through relaxation techniques, acupuncture, or exercise. However, these therapies alone don’t work for everyone. Some people also need treatment with medication to reduce the number of migraines they have. The drugs used to prevent migraines are different from drugs that to treat migraines once a migraine starts. Drugs that prevent migraines, such as gabapentin, must be taken daily.
For more information about Gabapentin, please check Gabapentin information in drugs.com or Gabapentin information in Webmd.com