How Gabapentin Works ?

How it works

  • Gabapentin is a medicine that may be used for the treatment of certain seizure disorders or nerve pain.
  • Experts aren’t sure exactly how gabapentin works, but research has shown that gabapentin binds strongly to a specific site (called the alpha2-delta site) on voltage-gated calcium channels. This action is thought to be the mechanism for the way it relieves nerve-pain and lowers the risk of seizures.
  • Gabapentin enacarbil (brand name Horizant) is a prodrug of gabapentin which has been designed to overcome the limitations of gabapentin, such as poor absorption and a short duration of action. Gabapentin enacarbil is effective for restless legs syndrome (RLS) and postherpetic neuralgia (nerve pain that occurs following Shingles).
  • Gabapentin belongs to the group of medicines known as anticonvulsants.