Gabapentin Interactions

Antiepileptic drugs (AEDs) have been associated with an increased risk of suicidal thoughts or behavior in patients taking these drugs for any indication. Pooled analyses of 199 placebo-controlled clinical studies involving the use of 11 different AEDs across multiple indications in either monotherapy or adjunctive therapy for a median treatment duration of 12 weeks (up to a maximum of 24 weeks) showed that patients receiving AEDs had approximately twice the risk of suicidal thinking or behavior compared to patients receiving placebo.

The estimated rate of suicidal behavior or ideation among 27,863 AED-treated patients was 0.43%, compared to 0.24% for 16,029 placebo-treated patients, representing an increase of approximately one case for every 530 patients treated. There were four suicides in AED-treated patients and none in placebo-treated patients, although the number is too small to establish any causal relationship.

The increased risk of suicidal thoughts or behavior was observed as early as one week after starting AEDs and persisted for the duration of treatment assessed. The risk did not vary substantially by age (5 to 100 years) in the clinical trials analyzed. Therapy with AEDs should be administered cautiously in patients with depression or other psychiatric disorders. The risk of suicidal thoughts and behavior should be carefully assessed against the risk of untreated illness, bearing in mind that epilepsy and many other conditions for which AEDs are prescribed are themselves associated with morbidity and mortality and an increased risk of suicidal thoughts and behavior.

Patients, caregivers, and families should be alert to the emergence or worsening of signs and symptoms of depression, any unusual changes in mood or behavior, or the emergence of suicidal thoughts or behavior. For clinically significant or persistent symptoms, a dosage reduction or treatment withdrawal should be considered.

If patients have symptoms of suicidal ideation or behavior, treatment should be discontinued.

Medications known to interact with gabapentin

Note: Showing generic names only.


Include all brand names and combination drug names.

      • acetylcarbromal
      • alfentanil
      • alprazolam
      • aluminum hydroxide
      • amitriptyline
      • amobarbital
      • amoxapine
      • apomorphine
      • apraclonidine ophthalmic
      • aripiprazole
      • asenapine
      • azatadine
B
      • baclofen
      • benztropine
      • biperiden
      • brexanolone
      • brexpiprazole
      • brimonidine ophthalmic
      • brimonidine topical
      • brivaracetam
      • bromocriptine
      • brompheniramine
      • buprenorphine
      • buspirone
      • butabarbital
      • butalbital
      • butorphanol
C
      • cannabidiol
      • cannabis
      • carbamazepine
      • carbetapentane
      • carbinoxamine
      • cariprazine
      • carisoprodol
      • cenobamate
      • cetirizine
      • chlophedianol
      • chloral hydrate
      • chlordiazepoxide
      • chlormezanone
      • chloroquine
      • chlorphenesin
      • chlorpheniramine
      • chlorpromazine
      • chlorzoxazone
      • cimetidine
      • citalopram
      • clemastine
      • clobazam
      • clomipramine
      • clonidine
      • clorazepate
      • clozapine
      • codeine
      • colesevelam
      • cyclobenzaprine
      • cyproheptadine
D
      • dantrolene
      • desipramine
      • desvenlafaxine
      • deutetrabenazine
      • dexbrompheniramine
      • dexmedetomidine
      • dextromethorphan
      • dezocine
      • dihydroxyaluminum sodium carbonate
      • diphenhydramine
      • divalproex sodium
      • doxepin
      • doxepin topical
      • doxylamine
      • dronabinol
      • droperidol
      • duloxetine
E
  • entacapone
  • escitalopram
  • esketamine
  • eslicarbazepine
  • estazolam
  • eszopiclone
  • ethanol
  • evening primrose
  • ezogabine
F
  • felbamate
  • fentanyl
  • flavoxate
  • flibanserin
  • fluoxetine
  • fluphenazine
  • flurazepam
  • fluvoxamine
  • fosphenytoin
G
  • ginkgo
H
  • halazepam
  • haloperidol
  • heroin
  • hydrocodone
  • hydromorphone
  • hydroxychloroquine
  • hydroxyzine
I
  • iloperidone
  • imipramine
  • isocarboxazid
K
  • kava
  • ketamine
L
      • lamotrigine
      • lasmiditan
      • lemborexant
      • levocetirizine
      • levomethadyl acetate
      • levomilnacipran
      • levorphanol
      • lithium
      • lofexidine
      • loxapine
      • lumateperone
      • lurasidone
M
  • magaldrate
  • magnesium carbonate
  • magnesium hydroxide
  • magnesium oxide
  • maprotiline
  • mefloquine
  • meperidine
  • meprobamate
  • mesoridazine
  • metaxalone
  • methadone
  • methocarbamol
  • metoclopramide
  • metyrosine
  • midazolam
  • milnacipran
  • mirtazapine
  • molindone
  • morphine
  • morphine liposomal
N
  • nabilone
  • nalbuphine
  • nefazodone
  • nortriptyline
O
  • olanzapine
  • oliceridine
  • olopatadine nasal
  • opicapone
  • opium
  • orphenadrine
  • oxazepam
  • oxcarbazepine
  • oxycodone
  • oxymorphone
P
      • paliperidone
      • paraldehyde
      • paroxetine
      • pemoline
      • pentazocine
      • pentobarbital
      • perampanel
      • pergolide
      • perphenazine
      • phenelzine
      • phenobarbital
      • phenytoin
      • pimozide
      • pramipexole
      • pregabalin
      • primidone
      • prochlorperazine
      • procyclidine
      • promazine
      • promethazine
      • propiomazine
      • propoxyphene
      • protriptyline
      • pyrilamine
Q
  • quazepam
  • quetiapine
R
  • ramelteon
  • rasagiline
  • remifentanil
  • risperidone
  • ropinirole
  • rotigotine
  • rufinamide
S
  • secobarbital
  • sertraline
  • sibutramine
  • sodium oxybate
  • st. john’s wort
  • stiripentol
  • sufentanil
  • suvorexant
T
      • tapentadol
      • tasimelteon
      • temazepam
      • tetrabenazine
      • thalidomide
      • thioridazine
      • thiothixene
      • tizanidine
      • tolcapone
      • tramadol
      • tranylcypromine
      • trazodone
      • triazolam
      • trifluoperazine
      • triflupromazine
      • trihexyphenidyl
      • trimeprazine
      • trimethobenzamide
      • trimipramine
      • tripelennamine
      • triprolidine
V
  • valbenazine
  • valerian
  • venlafaxine
  • vigabatrin
  • vilazodone
  • vortioxetine
Z
  • zaleplon
  • ziconotide
  • ziprasidone
  • zolpidem

Gabapentin alcohol/food interactions

There is 1 alcohol/food interaction with gabapentin

Gabapentin disease interactions

There are 4 disease interactions with gabapentin which include:

      • drug dependence
      • renal dysfunction
      • suicidal tendency
      • hemodialysis